---
name: pubmed-search
description: Search PubMed biomedical literature with natural language queries powered by Valyu semantic search. Full-text access, integrate into your AI projects.
keywords:
  - pubmed
  - biomedical-literature
  - medical-research
  - semantic-search
  - natural-language-queries
  - full-text-search
  - research-integration
license: MIT
---

# PubMed Search

Search the complete PubMed database of biomedical literature using natural language queries powered by Valyu's semantic search API.

## Why This Skill is Powerful

- **No API Parameter Parsing**: Just pass natural language queries directly - no need to construct complex search parameters
- **Semantic Search**: Understands the meaning of your query, not just keyword matching
- **Full-Text Access**: Returns complete article content, not just abstracts
- **Image Links**: Includes figures and images from papers
- **Comprehensive Coverage**: Access to all of PubMed's biomedical literature

## Requirements

1. Node.js 18+ (uses built-in fetch)
2. Valyu API key from https://platform.valyu.ai ($10 free credits)

## CRITICAL: Script Path Resolution

The `scripts/search` commands in this documentation are relative to this skill's installation directory.

Before running any command, locate the script using:

```bash
PUBMED_SCRIPT=$(find ~/.claude/plugins/cache -name "search" -path "*/pubmed-search/*/scripts/*" -type f 2>/dev/null | head -1)
```

Then use the full path for all commands:
```bash
$PUBMED_SCRIPT "CRISPR gene editing" 15
```

## API Key Setup Flow

When you run a search and receive `"setup_required": true`, follow this flow:

1. **Ask the user for their API key:**
   "To search PubMed, I need your Valyu API key. Get one free ($10 credits) at https://platform.valyu.ai"

2. **Once the user provides the key, run:**
   ```bash
   scripts/search setup <api-key>
   ```

3. **Retry the original search.**

### Example Flow:
```
User: Search PubMed for CAR-T cell therapy advances
→ Response: {"success": false, "setup_required": true, ...}
→ Claude asks: "Please provide your Valyu API key from https://platform.valyu.ai"
→ User: "val_abc123..."
→ Claude runs: scripts/search setup val_abc123...
→ Response: {"success": true, "type": "setup", ...}
→ Claude retries: scripts/search "CAR-T cell therapy advances" 10
→ Success!
```

## Usage

### Basic Search

```bash
scripts/search "your natural language query" [maxResults]
```

### Examples

```bash
# Search for recent COVID-19 research
scripts/search "COVID-19 vaccine efficacy studies" 15

# Find papers on a specific gene
scripts/search "BRCA1 mutations and breast cancer risk" 20

# Search for treatment approaches
scripts/search "immunotherapy for melanoma clinical trials" 10

# Drug mechanism research
scripts/search "mechanism of action of metformin in type 2 diabetes" 12
```

### Setup Command

```bash
scripts/search setup <api-key>
```

## Output Format

```json
{
  "success": true,
  "type": "pubmed_search",
  "query": "CRISPR gene editing",
  "result_count": 10,
  "results": [
    {
      "title": "Article Title",
      "url": "https://pubmed.ncbi.nlm.nih.gov/...",
      "content": "Full article text with figures...",
      "source": "pubmed",
      "relevance_score": 0.95,
      "images": ["https://example.com/figure1.jpg"]
    }
  ],
  "cost": 0.025
}
```

## Processing Results

### With jq

```bash
# Get article titles
scripts/search "query" 10 | jq -r '.results[].title'

# Get URLs
scripts/search "query" 10 | jq -r '.results[].url'

# Extract full content
scripts/search "query" 10 | jq -r '.results[].content'
```

## Common Use Cases

### Literature Review

```bash
# Find all papers on a topic
scripts/search "mechanisms of aging in humans" 50
```

### Drug Discovery

```bash
# Search for drug targets
scripts/search "novel targets for Alzheimer's disease treatment" 20
```

### Clinical Research

```bash
# Find clinical trial results
scripts/search "phase 3 trials for rheumatoid arthritis biologics" 15
```

### Gene Function

```bash
# Research gene function
scripts/search "role of TP53 in cancer development" 25
```

## Error Handling

All commands return JSON with `success` field:

```json
{
  "success": false,
  "error": "Error message"
}
```

Exit codes:
- `0` - Success
- `1` - Error (check JSON for details)

## API Endpoint

- Base URL: `https://api.valyu.ai/v1`
- Endpoint: `/search`
- Authentication: X-API-Key header

## Architecture

```
scripts/
├── search          # Bash wrapper
└── search.mjs      # Node.js CLI
```

Direct API calls using Node.js built-in `fetch()`, zero external dependencies.

## Adding to Your Project

If you're building an AI project and want to integrate PubMed search directly into your application, use the Valyu SDK:

### Python Integration

```python
from valyu import Valyu

client = Valyu(api_key="your-api-key")

response = client.search(
    query="immunotherapy for melanoma",
    included_sources=["valyu/valyu-pubmed"],
    max_results=20
)

for result in response["results"]:
    print(f"Title: {result['title']}")
    print(f"URL: {result['url']}")
    print(f"Content: {result['content'][:500]}...")
```

### TypeScript Integration

```typescript
import { Valyu } from "valyu-js";

const client = new Valyu("your-api-key");

const response = await client.search({
  query: "immunotherapy for melanoma",
  includedSources: ["valyu/valyu-pubmed"],
  maxResults: 20
});

response.results.forEach((result) => {
  console.log(`Title: ${result.title}`);
  console.log(`URL: ${result.url}`);
  console.log(`Content: ${result.content.substring(0, 500)}...`);
});
```

See the [Valyu docs](https://docs.valyu.ai) for full integration examples and SDK reference.